49. Comparing the ubiquitination and sumoylation pathways, which of the followingstatements are TRUE?
(1) Both types of protein modification can target proteins for proteasome-mediated degradation
(2) Both types of protein modification can be used to regulate DNA repair.
(3) Before modification, SUMOs need to be proteolytically processed.
 (4) Both types of modification can provide a new binding site for an interactingpartner.
 (5) For both types of modification, ligation occurs between a Gly residue onsubstrate proteins and a Lys residue on the modifiers.
(A) 234
(B) 135
(C) 245
(D) 123
(E) 345