【Its science-】評論
1.Severe combined immunodeficiency occurs in dogs and Arabian horses 2.mutation in DNA-PKcs 3. Affected dogs have normal numbers of circulating B lymphocytes that are unable to class switch to IgG or IgA and reduced numbers of T lymphocytes, which are nonfunctional due to the inability to express IL receptors4. Affected puppies are remarkably susceptible to bacterial and viral infections and rarely survive past 3 to 4 months of age.