問題詳情

27.CBF β-MYH11融合基因是下列何種染色體轉位？
(A)t(9;11)(p22;q23)
(B)inv(16)(p13;q22)
(C)t(15;17)(q22;q22)
(D)t(8;21)(q22;q22)

參考答案

答案：B
難度：簡單0.754789
統計：A(17),B(197),C(15),D(32),E(0)

用户評論

【蔡承叡】評論

M5    t(9;11)(p21;q23) KMT2A/MLLT3M4    inv(16)(p13q22) CBFB/MYH11M3   t(15;17)(q24;q21) PML/RARAM2   t(8;21)(q22;q22) RUNX1/RUNX1T1

【etrnya】評論

the pericentric inversion of chromosome 16, inv(16)(p13;q22), or its variant t(16;16)(p13;q22). The chromosome 16 abnormalities, which are closely associated with the FAB subtype M4Eo, result in the creation of a fusion gene between the smooth muscle myosin-heavy chain gene (MYH11) at 16p13 and the core binding factor(CBF) gene at 16q22. The fusion protein product, CBF-MYH11, interacts with nuclear corepressors, leading to dysregulation of transcription...