問題詳情

69 下列何種 β-adrenoceptor 拮抗劑之排除半衰期(elimination half-life)最短?
(A)bisoprolol
(B)esmolol
(C)nadolol
(D)propranolol

參考答案

答案:B
難度:適中0.6875
統計:A(0),B(22),C(3),D(0),E(0)

用户評論

一個人】評論

B. Esmolol has a rapid distribution half-life of about 2 minutes and an elimination half-life of about 9 minutesA. Bisoprolol has both lipid- and water-soluble properties.[18][22] It has an approximate half-life of 10–12 hours, and when ingested has high bioavailability (approx. 90%)C. The half-life of therapeutic doses of nadolol is about 20 to 24 hoursD. Propranolol is a highly lipophilic drug achieving high concentrations in the brain. The duration of action of a single oral dose is longer than the half-life and may be up to 12 hours, if the single dose is high enough (e.g., 80...