【Hua】評論
Lehninger Principles of Biochemistry, p. 817HMG-CoA reductase, an integral membrane protein of the smooth ER, is the major point of regulation on the pathway to cholesterol.膽固醇降低時，HMG-CoA reductase受SREBR-2活化而合成增加膽固醇升高時，phosphorylation促使HMG-CoA reductase蛋白降解
【annikalilin】評論
膽固醇合成第一步驟的酶，限速酶（rate-limiting enzyme）Cholesterol synthesis is tightly controlled by regulation at the HMG-CoA reductase step.