【Hua】評論

Viagra led to an increase in [cGMP] in penile vascular tissue, allowing vascular muscle relaxation, improved blood flow, and erection. 出處Reginald H. Garrett, Charles M. Grisham - Biochemistry 4th ed., p.404

【annikalilin】評論

威而鋼藉由活化水溶性環化鳥苷酸酶、抑制cGMP 磷酸二酯酶來增加cGMP胞內訊號分子A series of compounds, including nitroprusside, nitroglycerin, nitric oxide, sodium nitrite, and sodium azide, all cause smooth muscle relaxation and are potent vasodilators. These agents increase cGMP by activating the soluble form of guanylyl cyclase, and inhibitors of cGMP phosphodiesterase (eg, the drug sildenafil [Viagra]) enhance and prolong these responses.

【Pulpolyp】評論

這種cAMP、cGMP的合成、作用、分解的過程可以比較不嚴謹的寫成這樣的公式~而Viagra的主要作用就是透過抑制PDE5來使得cGMP沒辦法被分解，因此量一直累積一直去對PKG造成作用，最後令血管舒張而使血液充入陰莖，達成性功能障礙的治療