【Chris】評論

A complex of the UvrA and UvrB proteins (A2B) scans the DNA and binds to the site of a  lesion.  The  UvrA  dimer  then  dissociates,  leaving  a  tight  UvrB-DNA complex. UvrC protein then binds to UvrB, and UvrB makes an incision at the fifth phosphodiester bond on the 3′ side of the lesion. This is followed by a UvrC-mediated incision at the eighth phosphodiester bond on the 5′ side. The resulting 12 to 13 nucleotide fragment is removed by UvrD helicase. The short gap thus created is filled in by DNA polymerase I and DNA ligase....