【etrnya】評論

Acute promyelocytic leukemia (APML, APL)(在FAB分類上屬AML-M3級) is a subtype of acute myeloid leukemia (AML), a cancer of the white blood cells.[1] In APL, there is an abnormal accumulation of immature granulocytes called promyelocytes. The disease is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARα or RARA) gene and is distinguished from other forms of AML by its responsiveness to all-trans retinoic acid (ATRA; also known as tretinoin) therapy.STI-571 (imatinib, Gleevec, Glivec, CGP 57148) is an inhibitor of the Abl group of p...