【PPMTPASS】評論

Overview of heme synthesis. The formation of heme from glycine and succinyl CoA involves the sequential participation of eight different enzymes that are named as follows: δ-aminolevulinate synthase (ALA-S) (1); δ-aminolevulinate dehydratase (ALA-D) (2); porphobilinogen deaminase (PBGD) (3); uroporphyrinogen III synthase (URO-S) (4); uroporphyrinogen III decarboxylase (URO-D) (5); coproporphyrinogen III oxidase (CPO) (6); protoporphyrinogen III oxidase (PPO) (7); and ferrochelatase (FC) (8). Newly synthesized heme can be incorporated into heme proteins or, alternatively, can be degraded. Acc...