【用戶】Chris
【年級】高三下
【評論內容】Natural T-regulatory (nT reg ) cells develop in the thymus and are CD4-positive cells that constitutively express CD25 and high levels of the L-selectin receptor CD62L and of CTLA-4. Induced T reg (iT reg ) cells arise in the periphery from naive CD4 T cells and also express CD25 and CTLA-4.A hallmark of both natural and induced T reg cells is expression of the transcription factor FoxP3, which, among other actions, interferes with the interaction between AP-1 and NFAT at the IL-2 gene promoter, preventing transcriptional activation of the gene and production of IL-2.CD4 T cells ...
【用戶】Chris
【年級】高三下
【評論內容】Natural T-regulatory (nT reg ) cells develop in the thymus and are CD4-positive cells that constitutively express CD25 and high levels of the L-selectin receptor CD62L and of CTLA-4. Induced T reg (iT reg ) cells arise in the periphery from naive CD4 T cells and also express CD25 and CTLA-4.A hallmark of both natural and induced T reg cells is expression of the transcription factor FoxP3, which, among other actions, interferes with the interaction between AP-1 and NFAT at the IL-2 gene promoter, preventing transcriptional activation of the gene and production of IL-2.CD4 T cells ...