問題詳情
27. The nucleotide sequences of the p53 gene showed a single amino acid change inthe tumor mass, which compromised the protein's function. Which of the followingwould be true?
(A) Mutant p53 promotes adaptive responses to cancer-related stress conditionsto support tumor progression.
(B) Mutant p53 facilitates the establishment of a pro-oncogenic tumormicroenvironment.
(C) Mutant p53 enhances cancer cell survival under oxidative and genotoxicstress conditions.
(D) Mutant p53 induces G1 arrest and transcripts p21 after DNA damage.
(E) Mutant p53 imparts stem-like properties to cancer cells.
參考答案
答案:A,B,C
難度:計算中-1
書單:沒有書單,新增
用户評論
【涵涵(邀請碼107252)】評論
Stem cell-like cancer cell(幹細胞樣癌細胞),同時具有幹細胞和癌細胞的特徵,並保有自我更新和分化能力。細胞能跳脫細胞週期限制而不斷增生,不能就被稱為 Stem cell-like。原題目指出定序後發現 p53 單一胺基酸改變,p53可能失去正常成功或獲得非預期功能進而促使癌症產生,能促使癌細胞適應自身與環境壓力及增加存活。最為合適的答案為(A)、(C)在 Membranes 2022, 12(2), 202; Front Oncol.2020; 10: 595187 也指出: Mutant p53 通過改變正常的細胞分泌組,藉由旁分泌/自分泌信號、ECM 重塑、吸引基質細胞進入癌組織等機制協助促癌腫瘤微環境的建立。因此(B)也可。(A)、(B)、(C)均可