【Bryan】評論

Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the ß receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects.Milrinone, at relevant inotropic and vasorelaxant concentrations, is a selective inhibitor of peak III cAMP phosphodiesterase isozyme in cardiac and vascular muscle.Milrinone is not a beta-adrenergic agonist nor does it inhibit sodium-potassium adenosine triphosphatase activity as do the digitalis glycosides...

【Bryan】評論

This inhibitory action is consistent with cAMP mediated increases in intracellular ionized calcium and contractile force in cardiac muscle, as well as with cAMP dependent contractile protein phosphorylation and relaxation in vascular muscle.

【cctingood】評論

Amrinone與Milrinone都是PDE3 inhibitor 提高cAMP濃度, Ca↑,增心收縮力

【cctingood】評論

Amrinone與Milrinone都是☆☆☆3 ☆☆........

【Bryan】評論

This inhibitory action is consistent with cAMP mediated increases in intracellular ionized calcium and contractile force in cardiac muscle, as well as with cAMP dependent contractile protein phosphorylation and relaxation in vascular muscle.

【今症恩】評論

(A) Dobutamine : beta 1 agonist(B) Digoxigenin (C) Milrinone : inhibits the action of phosphodiesterase-3 and thus prevents degradation of cAMP(D) Ouabain : inhibiting the Na⁺/K⁺-ATPase sodium-potassium ion pump