【Bryan】評論

Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the ß receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects.Milrinone, at relevant inotropic and vasorelaxant concentrations, is a selective inhibitor of peak III cAMP phosphodiesterase isozyme in cardiac and vascular muscle.Milrinone is not a beta-adrenergic agonist nor does it inhibit sodium-potassium adenosine triphosphatase activity as do the digitalis glycosides...

【cctingood】評論

Amrinone與Milrinone都是PDE3 inhibitor 提高cAMP濃度, Ca↑,增心收縮力

【今症恩】評論

(A) Dobutamine : beta 1 agonist(B) Digoxigenin (C) Milrinone : inhibits the action of phosphodiesterase-3 and thus prevents degradation of cAMP(D) Ouabain : inhibiting the Na⁺/K⁺-ATPase sodium-potassium ion pump