【Celeste】評論
預防性藥物要越早使用越好,最好是 ≦ 6 小時內,超過 48 小時以上效果差,最晚不應超過 3 日在意外暴露後的適當的預防性投藥(postexposureprophylaxis,PEP)
【MJ Chang】評論
Basic two-drug postexposure prophylaxis(PEP) is generally recommended for less severe percutaneous exposures (solid needle or superficial injury) from an HIV-positive patient who is suppressed on antiretrovirals, a patient with an unknownHIV statuswho has HIV risk factors, or formucous membrane exposures. Basic two-drug PEP generally consists of two NRTIs such as zidovudine, stavudine, or tenofovir with lamivudine or emtricitabine.Expanded three-drug PEP is recommended for more severe percutaneous exposures (large-bore hollow needle or deep puncture wound) from suppressed HIV-positive patients...
【H.W. C】評論
-暴露後四小時內有最佳預防效果,盡量在48/72 hr內投藥,持續四週-drug: TDF/FTC (or 3TC/ZDV) +RAL BID or +DRV/r QD or +LPV/r BID或者 TDF/FTC + DTG QD