【用戶】心想事成
【年級】大一下
【評論內容】(A) Lamivudine不怎麼代謝的，幾乎是原型在尿液排出，也不太影響CYP(B)(C) protease inhibitor (PI) 是 CYP3A4 inhibitor，自然而然會與CYP代謝的methadone有交互作用。(D) Methadone levels remained in the therapeutic range during ZDV treatment. These effects resulted primarily from inhibition of ZDV glucuronidation, but also from decreased renal clearance of ZDV. This study confirms that methadone-maintained patients receiving standard ZDV doses experience greater ZDV exposure and may be at increased risk for ZDV side effects and toxicity. (https://www.ncbi.nlm.nih.gov/pubmed/9715839...
【用戶】ㄨㄚˊ我什麼都不會
【年級】高三上
【評論內容】UpToDateMethadone may enhance the QTc-prolonging effect of Saquinavir. Saquinavir may decrease the serum concentration of Methadone. The mechanism of this interaction is uncertain. AUC changes reported with saquinavir / ritonavir are close to those reported with ritonavir alone at similar doses,6,7,8 so the role of saquinavir in the interactions is questionable. Ritonavir could theoretically induce methadone metabolism, particularly via CYP2B6.9