【用戶】7you
【年級】國一下
【評論內容】記得Acute 和 chronic leukemia 重要區分是 20% blast : acute leukemia >20% blast ;反之所以 (A) 周邊血中有持續性monocytosis，超過1.0 × 109/L，且骨髓中blast cells > 20% >>>直接破題BCR-ABL1 translocation >>for CML補充CMMoL診斷標準 :Persistent peripheral blood monocytosis with counts >1x109/LNo Philadelphia chromosome or BCR-ABL1 fusion geneNo rearrangement of PDGFRA or PDGFRB gene<20% myeloblasts, monoblasts and promonocytes in peripheral blood or bone marrowDysplasia in one or more of the myeloid lineages; if myelodysplasia is absent or minimal then a diagnosis of CMML can be made if other requirements are met and:A molecular genetic abnormality is present in haematopoietic cells, orMonocytosis present for ≥3 months and other causes of monocytosis have been ruled outCMMoL基因變異 : The most common found are the 8+, −7/del (7q) and structural 12p abnormalities.TET2 Mutations gene : 40–50%KRAS and NRAS mutate : 25–40% Mutations in transcription factors such as RUNX1, CEBPA, NPM1 and WT1 : 30%Jak2 V617F mutation : 10% CBL Mutations : 5–18% https://en.wikipedia.org/wiki/Chronic_myelomonocytic_leukemia