【DD】評論
氯乙烯所致肝血管肉瘤又稱血管內皮細胞肉瘤或惡性血管內皮瘤,是由肝竇細胞異形增生所形成的原發性惡性腫瘤。它是血管源性惡性腫瘤中最常見的一種。55 歲男病人在塑膠工廠工作有 25 年,因體重下降,且噁心及嘔吐超過 3 個月而求診。電腦斷層掃描 發現肝臟有 10 公分大的腫瘤,切片檢查證實肉瘤(sarcoma),請問該病人在工作場所最可能暴露於 下列何種物質所引起? (A) 苯(benzene) (B)石綿(asbestos) (C)氯乙烯(vinyl chloride) (D)石蠟油精(naphthalene)93.氯乙烯單體會造成下列那一項職業性癌症? (A)白血病 (B)肺癌 (C)肝血管肉瘤 (D)腦瘤
【Chris】評論
Aromatic hydrocarbons(e.g., benzene and naphthalene)metabolized by CYP2E1 to toxic metabolites that disrupt marrow hematopoiesis, leading to dose-dependent aplasia and an increased risk of acute myeloid leukemia.Asbestos• Localized pleural plaques and effusions or, rarely, diffuse pleural fibrosis• Parenchymal interstitial fibrosis (asbestosis)• Lung carcinoma, malignant mesothelioma, and laryngeal and other extrapulmonary neoplasmsvinyl chloridelive sarcom...