【Jason Chen】評論

(A)Vancomycin主要依據病人腎功能來調整劑量 (B)肥胖的病人應該用理想體重(ideal body weight)計算vancomycin給藥劑量，且受每日最高劑量2g之限制 (肥胖病人用實際體重給藥，血中濃度會較高)(C)根據vancomycin谷濃度（trough concentration）調整劑量來確保療效 (D)Vancomycin波谷濃度（trough concentration）須小於 15 mg/L (10~15 mcg/mL)波峰濃度（peak concentration）須小於 45 mg/L (30~45 mcg/mL)

【Celeste】評論

66.一般而言，vancomycin適宜之治療血中波谷（trough）濃度範圍為何？ (A)5~8 mg/L (B)10~15 mg/L (C)25~30 mg/L (D)35~48 mg/L專技高考◆藥師(二)◆調劑學與臨床藥學- 104年 - 104-1-藥師(二)-調劑學與臨床藥學#19188

【CC Lu】評論

trough concentration須大於10 mg/L 以免產生抗藥性

【H.W. C】評論

臨床上vanco治療濃度建議：Vancomycin efficacy is linked to a correct dosage which should aim to reach an area under the curve (AUC)/MIC ratio of ≥400; serum trough levels of 15 to 20 mg/liter are considered a surrogate marker of an AUC/MIC ratio of ≥400 for a MIC of ≤1 mg/liter. For Staphylococcus aureus strains presenting with a MIC 1 mg/liter, an alternative agent should be considered. Vancomycin doses must be adjusted according to body weight and the plasma trough levels of the drug.Nephrotoxicity has been associated with target vancomycin trough levels above 15 mg/liter.Álvarez R,...