【Swear】評論

Coadministration with ACE inhibitors may increase serum lithium concentrations and the risk for lithium toxicity. Several mechanisms may be involved, one of which is rduced renal lithium clearance due to natriuresis secondary to the inhibition of aldosterone and angiotensin II by ACE inhibitors. The combination may also cause renal dysfunction secondary to volume depletion during chronic therapy, which can further impair lithium clearance.

【Rose Tsai】評論

(B)increased CNS response to lithium

【蔡芝蓉】評論

覺得沒答案

【Sky】評論

Losartan也會造成濃度上升Concurrent use of LITHIUM and ANGIOTENSIN RECEPTOR BLOCKERS may result in increased risk of lithium toxicity.Coadministration of lithium and this drug may increase the risk of lithium toxicity. If concomitant use is required, reduce the initial lithium dosage, titrate slowly, and frequently monitor serum lithium concentrations and for signs of lithium toxicity (Prod Info LITHOBID® oral extended release tablets, 2016).ref:Micromedex

【iamlin】評論

 losartan 主要由肝代謝