問題詳情

8.下列有關膠原凝集素（collectins）之敘述，何者正確？
(A)Surfactant protein A、surfactant protein D及ficolins均屬於其家族之成員
(B)其單體結構之N-terminus為C-type lectin區域，C-terminus則為類似膠原蛋白（collagen-like）之區域
(C)屬於先天性免疫之成員，且為模式識別受體 PRRs（pattern recognition receptors）
(D)其結構通常為多聚體，例如mannose-binding lectin結構主要為二聚體或五聚體

參考答案

答案：C
難度：困難0.357
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(A) Surfactant protein A、surfactant protein D及ficolins均屬於其家族之成員-----ficolins是另外一個lectin familycollectins innate immune systemcollagenous lectins Ca2 dependent proteinssoluble pattern recognition receptors (PRRs)-->bind PAMPs & DAMPsstucture C-type lectin domain that is also called carbohydrate recognition domain (CRD)  Ca2collagen-like domaincysteine-rich domain at the N-terminuscoiled-coil neck domaina -------------------------------------------------------------------------------------ficolins  innate immunitycollagenous lectinspattern recognition receptorsproduced in the liver from wiki