問題詳情

54.下列有關藥物Phase II代謝中的酵素與基質提供者的對應，何者錯誤？
(A)methyl transferase－S-adenosylmethionine
(B)glutathione S-transferase－glutathione
(C)sulfotransferase－3-phosphoadenosine-5'-phosphate
(D)acyl synthetase－glycine

參考答案

答案：C
難度：簡單0.714286
統計：A(1),B(3),C(30),D(8),E(0)

用户評論

【jhihrong】評論

共軛反應共軛劑高能量中間物發生共軛官能基glucuronidationglucuronic acidUDPGA-OH、-COOH、-NH2、SHSulfationSulfatePAPS-OH、-NH2amino acidglycinecoenzyme A thioester-COOHacetylationacetyl CoAacetyl CoA-OH、-NH2methylationCH3 from S-adenosylmethionineS-adenosyl-methionine-OH、NH2glutathione (mercapturic acid conjugation)GlutathioneArene oxides, epoxides(可參考下圖)aryl halides, epoxides, arene oxides參考資料：建材大本本、https://www.pharmacologicalsciences.us/pharmaceutical-chemistry/ho.htm...

【Hikari】評論

1. Glucuronidation (35%) 醛糖酸化：(elecrtophile) (1) Enzyme：UDP-glucuronosylntransferase (UGT) (2) Cofactor：uridine-5’-diphospho-D-glucuronicnacid(UDPGA) 2. Sulfonation 硫酸化：(elecrtophile) (1)nEnzyme：sulfotransferase (ST)  (2)nCofactor:：3’-phosphoadenosine-5’-phosphosulfate (PAPS)3. Glutathione conjugation 麩胱胺酸化：(nucleophile) (1)nEnzyme：glutathione S-transferase  (2)nCofactor：glutathione4. Acetylation 乙醯化：(elecrtophile)(1)nEnzyme：acetyltransferase  (2)nCofactor：acetyl coenzyme A 5. Methylation 甲基化：(elecrtophile)(1)nEnzyme：methyl transferase  (2)nCofactor：S-...

【Hikari0108】評論

1. Glucuronidation (35%) 醛糖酸化：(elecrtophile) (1) Enzyme：UDP-glucuronosylntransferase (UGT) (2) Cofactor：uridine-5’-diphospho-D-glucuronicnacid(UDPGA) 2. Sulfonation 硫酸化：(elecrtophile) (1)nEnzyme：sulfotransferase (ST)  (2)nCofactor:：3’-phosphoadenosine-5’-phosphosulfate (PAPS)3. Glutathione conjugation 麩胱胺酸化：(nucleophile) (1)nEnzyme：glutathione S-transferase  (2)nCofactor：glutathione4. Acetylation 乙醯化：(elecrtophile)(1)nEnzyme：acetyltransferase  (2)nCofactor：acetyl coenzyme A 5. Methylation 甲基化：(elecrtophile)(1)nEnzyme：methyl transferase  (2)nCofactor：S-...