【Chris】評論

In Trisomy 21 (Down’s syndrome), the c’some 21 codes for beta amyloid, and if you have three of these, you will make more beta amyloid protein.  And beta amyloid protein is toxic to neurons; so, if you have trisomy 21 are making more beta amyloid protein, then you will be losing more neurons b/c you are losing more of this protein that is toxic to neurons.  This is why they always ask the question about a pt dying at forty and on autopsy, you see atrophy of the brain and it reveals senile plaques in frontal and temporal lobes, and will ask what pt had – Down’s syndrome.  All down’s pts...