【用戶】Chamomile
【年級】國二上
【評論內容】補充整理~~~特殊代謝- Cyclophosphamide：經CYP2B6代謝 →4-hydroxycyclophosphamide (carbinolamine)→→acrolein(出血性膀胱炎)+phosphoramide mustard(環化成aziridium)- Paclitaxel：經CYP2C8代謝 →6α-hydroxypaclitaxel- Dacarbazine：經CYP1A- Cisplatin：體內脫Cl後產生diaquo form (活性最強)- Anthracycline類：經reductase還原產生anthracycline hydroquinone+自由基- Mitoxantrone：N-demethylation→deamination→aldehyde dehydrodenase →glucuronide conjugation (有分子內氫鍵，不會經reductase→*沒有心毒性)- Azathi...
【用戶】Chamomile
【年級】高一上
【評論內容】補充整理~~~特殊代謝- Cyclophosphamide：經CYP2B6代謝 →4-hydroxycyclophosphamide (carbinolamine)→→acrolein(出血性膀胱炎)+phosphoramide mustard(環化成aziridium)- Paclitaxel：經CYP2C8代謝 →6α-hydroxypaclitaxel- Dacarbazine：經CYP1A- Cisplatin：體內脫Cl後產生diaquo form (活性最強)- Anthracycline類：經reductase還原產生anthracycline hydroquinone+自由基- Mitoxantrone：N-demethylation→deamination→aldehyde dehydrodenase →glucuronide conjugation (有分子內氫鍵，不會經reductase→*較無心毒性)- Azathi...