56. Transcriptome analysis is a tool used in genetic research to determine the mRNAs being produced ina particular tissue, and their relative level of expression. Known genes can therefore be assayed fortheir expression in different situations. One use of the technology is in cancer diagnosis and treatment.If a known gene functions as a tumor suppressor, predict which of the following pieces of evidencewould be most useful in diagnosis of a cancer due to a mutation in this tumor-suppressor gene.
(A) The tissue sample shows a high level of gene expression relative to a control (noncancerous)sample.
(B) The tissue sample responds to treatment with a mitosis-promoting compound.
(C) The tissue sample shows similar expression level of housekeeping genes with a control sample.
(D) The mRNAs for cyclins and kinases show unusually high levels of expression.
(E) The mRNAs for the targeted tumor suppressor sequence are not expressed.