【Bryan】評論

Tetracyclines are broad-spectrum antibiotics derived from cultures of Streptomyces bacteria, and work by inhibiting protein synthesis after uptake into susceptible organisms. They work by reversibly binding to the 30S ribosome of the microbial RNA and preventing the attachment of aminoacyl-tRNA with the acceptor site on the 70S ribosome. Their activity is bacteriostatic and not bacteriocidal.

【王瑜】評論

作用在30S的只有AMG和四環

【黃林】評論

Clindamycin 作用在50S

【軒】評論

資料來源：劉老師上課講義Amphenicol : reversibly 50S binding, inhibit peptidyl transferase (transpeptidation)新的tRNA進不來Macrolide : 50S binding inhibit translocationRNA無法自 A site 轉 P siteTetracycline : 30S binding新的tRNA進不來

【鐵觀音鮮奶茶 無去】評論

tetracycline：bind reversibly 菌體核糖體 ribosome 的 30S subunit。→ 阻斷amino-acyl-tRNA轉錄至mRNA-ribosome complex 核糖複合體結合位置 (A site)。→ 防止amino acids加到延伸的peptide上→ 抑制蛋白質合成。