【Bryan】評論

Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions.

【今症恩】評論

(A)Methotrexate：抑制葉酸合成(B)Uracil mustard ：Alkylating agent(C)Vincristine ：抑制微管(D)Bleomycin：Breaks DNA

【鐵觀音鮮奶茶 無去】評論

葉酸拮抗劑 Dihydrofolate reductase inhibitorMethotrexate(MTX)·結構類似葉酸(folic acid)。·抑制 二氫葉酸還原酶 DHFR，導致 7,8-DHF 累積。→ 產生負回饋作用抑制 thymidylate Synthetas，細胞進行thymineless death。