【Chris】評論

(A)APC/ β-catenin 當Wnt蛋白與細胞表面Frizzled受體家族結合後，抑制下游蛋白質複合物，包括axin、GSK-3、與APC蛋白。axin/GSK-3/APC 複合體可促進細胞內信號分子β-catenin的降解。當「β-catenin 降解複合物」被抑制後，胞漿內的β-catenin得以穩定存在，部分 β-catenin進入細胞核與TCF/LEF轉錄因子家族作用並促進特定基因的表達。(B)PTEN A  PIP3-specific  phosphatase  (PTEN  inhumans) removes the phosphoryl group at the 3 position of PIP3 to producePIP2,  which  no  longer  serves  as  a  binding  site  for  PKB,  and the signaling chain is broken.(C)RB1 在G1 checkpoint有cyclinE/CDK2可以將Rb磷酸...

【一個人】評論

WIKI : BRCA1 and BRCA2 are unrelated proteins,[10] but both are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA, or destroy cells if DNA cannot be repaired. They are involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double-strand breaks.[11][12] If BRCA1 or BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cance...