問題詳情

17.針對抗利尿激素ADH受體拮抗藥物tolvaptan具有利尿作用，其主要作用在collecting tubule以干擾下列何種管道（channel）？
(A)aquaporin
(B)Na+
(C)K+
(D)Cl

參考答案

答案：A
難度：適中0.5
統計：A(7),B(5),C(2),D(0),E(0)

用户評論

【用戶】GE

【年級】大一下

【評論內容】conivaptan ：vasopressin antagonist (both V1a and V2 receptors)Tolvaptan：vasopressin antagonist (V2 receptors)Ref. Basic and Clinical Pharmacology, 14th Edition

【用戶】GE

【年級】大一下

【評論內容】conivaptan ：vasopressin antagonist (both V1a and V2 receptors)Tolvaptan：vasopressin antagonist (V2 receptors)Ref. Basic and Clinical Pharmacology, 14th Edition

【用戶】如果詳解被鎖找 北醫王瑞賢

【年級】高一上

【評論內容】【解題】整理自14th Basic & clinicalnpharmacology p.258內文、256表格內文ADH1.調控水通道蛋白(Aquaporin)控制遠曲小管的水分通透性2.V1受體：中樞、血管3.V2受體：腎臟   (V2為Gs→cAMP路徑)4.Tolvaptan為選擇性V2 ADH Antagonist→可治SIADH【附上原文】Antidiuretic hormone (ADH, also called arginine vasopressin, AVP) controls the permeability of these cells to water by regulating the insertion of pre-formed water channels (aquaporin-2, AQP2) into the apical membrane. Vasopressin receptors in the vasculature and central nervous system (CNS) are V1 receptors, and those in the kidney are V2 receptors. V2...