【評論主題】49.有一藥品靜脈注射給予50 mg後，血中濃度估算公式：C(t)=4e-1.386t +1e-0.0866t。同藥口服給藥50mg後，血中濃度估算公式：C(t)=0.267e-0.0866t – 0
【評論內容】
電算機按一按，碼錶計時1分24秒！
【評論主題】49.有一藥品靜脈注射給予50 mg後，血中濃度估算公式：C(t)=4e-1.386t +1e-0.0866t。同藥口服給藥50mg後，血中濃度估算公式：C(t)=0.267e-0.0866t – 0
【評論內容】
45秒內要算出這個答案喔！
【評論主題】16.下列何者非為半固體劑型？(A)軟膏劑 (B)硬膏劑 (C)乳霜劑 (D)懸液劑
【評論內容】A suspension is a liquid with small pieces of drug.
【評論主題】42.下列有關levorphanol與dextrorphan之敘述，何者正確？(A)Levorphanol有鎮痛效用，dextrorphan有鎮咳效用(B)二者之立體關係互為diastereomeri
【評論內容】
Dextromethorphan經過CYP2D6 O-demethylation代謝產生dextrorphan
【評論主題】42.下列有關levorphanol與dextrorphan之敘述，何者正確？(A)Levorphanol有鎮痛效用，dextrorphan有鎮咳效用(B)二者之立體關係互為diastereomeri
【評論內容】
Dextromethorphan經過CYP2D6 O-demethylation代謝產生dextrorphan
【評論主題】70.下列何者不屬於臨床用強心苷的必要結構？(A)C14β-OH(B)C17α-unsaturated lactone(C)ring A-B cis fused(D)ring C-D cis fuse
【評論內容】
(A)C14β,C3β-OH(B)C17β-unsaturated lactone(C)ring A-B cis fused(D)ring C-D cis fused
ring B-C trans fused
【評論主題】9.以毛細管電泳法分析R及S form的mepivacaine時，於背景電解質溶液0.1 M phosphate buffer（pH 3.0）中添加下列何者可獲得最好的分離效果？(A)10 mM SD
【評論內容】CE毛細管電泳，GC
，HPLC皆可利用cyclodextrin分離鏡像異構物。
【評論主題】6.單溴取代化合物之質譜分子峰中[M]與[M+2]之強度比為何？(A)1:1(B)2:1(C)3:1(D)4:1
【評論內容】
http://web.nchu.edu.tw/pweb/users/splin/lesson/9514.pdf
P.25
C-13 1.1%: small M+1 peak
Br: [M+]:[M+2]=1:1
Cl: [M+]:[M+2]=3:1
I: PEAK AT 127,large gap
N:[M+]呈奇數
S: [M+]:[M+2]=100:4
【評論主題】78.某藥的正常劑量為10 mg/kg，bid，正常排除半衰期為100分鐘，當某病患服用此藥物時，其排除半衰期為150分鐘，若給藥劑量維持一定時，投藥間隔應調整為多少小時？(A)8(B)18(C)12
【評論內容】
T1/2=0.693/k
Css=FD0/kxVdx( tau )
k和t1/2或tau都成反比，所以t1/2和tau成正比
bid=間隔12hr
t1/2和tau成正比 100/150=12/18
【評論主題】34.那一項製劑會因活性成分干擾，不能使用LAL（Limulus amebocyte lysate）法測定內毒素？(A)血漿蛋白(B)Pentobarbital sodium注射液(C)無菌注射用水(
【評論內容】
Oxacillin,sulfisoxazole,vancomycin不可進行LAL test
【評論主題】7.有關藥師執業，下列事項何者正確？(A)某藥師於某年2月1日自臺北榮總離職，同年6月1日至高雄榮總就職，該藥師應向高雄市政 府辦理變更執業處所登記 (B)某藥師於臺北榮總工作時已加入臺北市藥師公會，
【評論內容】
依藥師法第十條：藥師停業或歇業(離職)時，應自事實發生之日起30天內，報請原發執業執照之主管機關備查。
http://www.kpa.org.tw/GoodsDescr.asp?category_id=57&parent_id=0&prod_id=57-09
【評論主題】45.下列何種情境須調低藥品劑量？(A)靜脈栓塞病人服用warfarin 1.25 mg qd, INR 1.5 (B)氣喘病人服用theophylline 400 mg qd, serum theo
【評論內容】
http://accessmedicine.mhmedical.com/content.aspx?bookid=1069§ionid=60775149
Clinical Laboratory Reference Values
6mEq/L應該不等於6mg/L吧！
怎麼感覺這題有瑕疵？
【評論主題】21.若一高血壓病人同時患有糖尿病，則下列那一種降壓藥物較不會使血糖升高？(A)Carteolol (B)Metoprolol (C)Nadolol (D)Verapamil(E)送分
【評論內容】
http://heart-disease.emedtv.com/metoprolol/metoprolol-and-low-blood-sugar.html
Does Metoprolol Cause Low Blood Sugar?Metoprolol (Lopressor®, Toprol XL®) belongs to a group of medications known as beta blockers. Low blood sugar levels have been reported in people taking such drugs. Normal doses of metoprolol probably do not significantly increase the risk of low blood sugar for most people. However, Toprol-XL can make low blood sugar less noticeable (which can be dangerous, especially for people with diabetes). This potential side effect of beta blockers is more common in infants and children...
【評論主題】9.全靜脈營養輸液（TPN）持續使用多少天後，須開始監測血中微量元素（trace elements）？(A)7 (B)14 (C)21 (D)28
【評論內容】
TPN（全靜脈營養）與PPN（周邊靜脈營養）都是經由血管灌輸營養的一種方式，兩者的異同點如下：輸注點的選擇：TPN必須選擇較粗大的靜脈（一般選擇中心靜脈）作為入注點，PPN則可選用較細的靜脈（如周邊靜脈）
輸液的濃度：TPN輸液的濃度較高，滲透壓亦較大，故必須從較粗大的靜脈注輸；PPN輸液濃度較低，故可從管徑較粗的靜脈輸注。
病患選擇：TPN是用在病情較嚴重，營養需求較高的病患，如ICU（加護病房）的患者，和血管灌輸營養使用時間較久者；PPN使用於需要短暫血管營養補充的較輕病患者（註：一般PPN的使用以不超過兩周為原則，太久會出現副作用）使用PPN的患者如超過兩周仍需要繼續靜脈營養補充，則可以轉換成TPN給予。
輸液營養成分內容：...
【評論主題】21.下列何者會減少L-dopa的代謝？(A)amantadine (B)carbidopa (C)dopamine (D)selegiline
【評論內容】
Carbidopa可以抑制L-dopa被AADC代謝成dopamine
Selegiline可以抑制dopamine被MAO-B代謝成DOPAC
【評論主題】63.下列何者成分之歸類不屬於phenylpropanoid？(A)khellin (B)coumarin (C)rutin (D)emodin
【評論內容】emodin—anthraquinone glycoside
【評論主題】47.Emodin之生合成前驅物（precursor）為：(A)mevalonic acid (B)tyrosine (C)shikimic acid (D)acetate
【評論內容】
http://patentimages.storage.googleapis.com/WO2011089602A2/imgf000041_0001.png
【評論主題】28.下列何種儀器用於定量分析時，在適當條件下其可偵測極限濃度最低？(A)質譜儀 (B)紅外光光譜儀 (C)紫外光光度儀 (D)核磁共振光譜儀
【評論內容】
http://mob.muchong.com/html/200903/1218026.html
GC/MS的Sensitivity是10-12，LC/MS的Sensitivity是10-15，CE/MS的Sensitivity是10-23，NMR的Sensitivity是10-6【評論主題】62.病人準備接受第3次的化療，檢驗值：WBC 1,500 cells/mm3；RBC 4,000 cells/mm3；platelet 10,000 cells/mm3，下列何種處置最適當？ (A)
【評論內容】
IL-11=Oprelvekin
G-CSF=Filgrastim
【評論主題】32.造口（ostomy）之術後照護及相關醫材供應是藥事服務之領域。藥師對具ileostomy或colostomy病人提供用藥建議或諮詢，下列何者錯誤？ (A)應儘量避免enteric coated製
【評論內容】
General PrinciplesIn order to minimize problems with drug absorption, follow these general principles. For the ileostomy patient, dosage forms with quick dissolution (dissolving tablets) and absorption should be used. Liquids, gelatine capsules, and uncoated tablets are usually better and well absorbed. Dosage forms such as enteric coated and sustained release products should be avoided due to the possibility of poor absorption. Enteric coating is designed to prevent stomach lining irritation from direct contact with certain drugs, such as aspirin. Sustained release products are designed so th...
【評論主題】57.下列何者不是pharmaceutical equivalents之必備要件？(A)相同給藥劑量 (B)相同給藥劑型 (C)相同給藥途徑 (D)相同藥物釋放機轉
【評論內容】
http://m.authorstream.com/presentation/001gaurav11288-1613594-drug-release-mechanisms/
Drug release mechanism and models of release kinetics
【評論主題】49.有一藥品靜脈注射給予50 mg後，血中濃度估算公式：C(t)=4e-1.386t +1e-0.0866t。同藥口服給藥50mg後，血中濃度估算公式：C(t)=0.267e-0.0866t – 0
【評論內容】
電算機按一按，碼錶計時1分24秒！
【評論主題】49.有一藥品靜脈注射給予50 mg後，血中濃度估算公式：C(t)=4e-1.386t +1e-0.0866t。同藥口服給藥50mg後，血中濃度估算公式：C(t)=0.267e-0.0866t – 0
【評論內容】
45秒內要算出這個答案喔！
【評論主題】31.下列何種粉碎機器，一般得到之粒子較大？(A)Roller mill (B)Ball mill (C)Fluid-energy mill (D)Colloid mill
【評論內容】
http://tw.foodsourcings.com/user-space/prod-39911-7683
Colloid mill
【評論主題】16.下列何者非為半固體劑型？(A)軟膏劑 (B)硬膏劑 (C)乳霜劑 (D)懸液劑
【評論內容】A suspension is a liquid with small pieces of drug.
【評論主題】40.氣相層析的頂空分析（head space analysis）是新的進樣方式，下列敘述何者錯誤？(A)檢品注入管柱頂端，加熱後直接進入管柱分析(B)檢品於封裝（sealed）小瓶中加熱，氣化成分以
【評論內容】Splitless InjectionYou are here:
Splitless Injection
In splitless mode the split vent is closed during the first part of the injection. This means that the sample can only go down the column. This leads to much higher detection limits because most of the sample will go down the column instead of out the split vent. Splitless is used for low concentration samples. One thing to remember about splitless is that the gas flow through the liner is equal to the column flow. So the flow through the liner could be as low as 0.5ml/ min. This means you have to wait longer to flush the sample into the colum...
【評論主題】42.下列有關levorphanol與dextrorphan之敘述，何者正確？(A)Levorphanol有鎮痛效用，dextrorphan有鎮咳效用(B)二者之立體關係互為diastereomeri
【評論內容】
Dextromethorphan經過CYP2D6 O-demethylation代謝產生dextrorphan
【評論主題】20.有一心衰竭與高血壓病人正服用Digoxin中，則下列何種利尿劑較適合用來作為降壓劑？(A)Acetazolamide(B)Eplerenone(C)Bumetanide(D)Hydrochlor
【評論內容】
Triamterene,Amiloride: Na channel blocker
Spironolacrone,Eplerenone: aldosterone blocker
【評論主題】28.下列消化性潰瘍治療藥物，何種是抑制H+, K+-ATPase？(A)Sucralfate(B)Lansoprazole(C)Famotidine(D)Antacids
【評論內容】
H+, K+-ATPase即proton pump
選proton pump inhibitor(-prazole)
【評論主題】5.下列那一組抗生素併用可產生拮抗作用而降低抑菌效果？(A)Clavulanate + Ticarcillin(B)Piperacillin + Tobramycin(C)Chloramphenico
【評論內容】
灰黴素 Griseofulvin