36. Which of the following description about topoisomerase is (are) CORRECT?
(A) Both prokaryotes and eukaryotes have topoisomerases that are capable of removing supercoilds from
DNA.
(B) Topoisomerases use a covalent protein-DNA linkage to cleave and rejoin DNA strands.
(C) Topoisomerase are of two general types. In contrast to type II, type I topoisomerase do not require the
energy of ATP hydrolysis.
(D) Topoisomerase can also decatenate, disentangle and unknot DNA.
(E) Topoisomerases are required in many cellular processes, such as transcription, replication and
recombination, and are the target of several cancer chemotherapeutic agents.