7. For substrates of spinal cord nociceptive processing, which one of the following statement iswrong?
(A) The dorsal root ganglion and brainstem nuclei are home to second-order neurons, the first stepof central nervous system (CNS) processing.
(B) Although it seems like a simple statement that pain-related second-order neurons are theneurons which receive primary afferent input related to tissue damage (i.e., from nociceptors), itmust be accepted that this statement may or may not be wholly true because in certainpathologic states, pain can be evoked by non–tissue-damaging stimuli (allodynia).
(C) A proto-oncogene, c-fos, is activated after potentially tissue-damaging stimuli are applied tomost tissues.
(D) A systematic comparison study of Fos and pERK as markers of spinal nociceptive activationrevealed greater specificity for activity in nociceptive pathways (vs. nonnociceptive activation)using pERK.
(E) Analgesic pharmacologic manipulations such as systemic morphine reduce both the totalnumber of labeled neurons and the total Fos or pERK content of the spinal cord following anoxious stimulus.