6. For peripheral pain mechanisms and nociceptor sensitization, which one of the followingstatement is wrong?
(A) Sensory neurons commonly identified as nociceptors are those with myelinated (A-fiber) axons,big cell body diameters (＞ 50 μm), that terminate in the deep layers of the spinal cord dorsalhorn.
(B) The presence or absence of certain markers (e.g., the tetrodotoxin (TTX)-resistant sodiumchannel NaV1.8, the transient receptor potential vanilloid receptor TRPV1) have been used toidentify subsets of nociceptors.
(C) More recently, with the ability to analyze many genes expressed in a single cell, patterns ofgene expression have been used to further define subpopulations of nociceptors.
(D) With respect to cell body size and myelination, it should be appreciated that there exist somelarge diameter cells with heavily myelinated and rapidly conducting axons that have beendocumented functionally to be nociceptors.
(E) Many non-nociceptors have unmyelinated axons, and thus, axon myelination or cell diametercannot be applied as reliable criteria to define a nociceptor.