【小羊】評論

(A)  Mitomycin: 1. Quinone → Free radical。2. Aziridine → Alkylating。3. Carbamate(Urethane) → Alkylating。(B)  5-FU:需轉換成5-FdUMP抑制thymidylatesynthetase使N5，N10-methylene tetrahydrofolic acid (leucovorin) 輔酶無法進行反應。(C)  Cisplatin:會進入細胞在低氯環境中釋出Cl，接著藥物會結合DNA 中guanine的N7而形成股間與股內的交互連結。(D)  Tretinoin:又稱trans-retinoicacid，進入細胞核予PML-RAR反應，除去co-repressor吸引co-activator，治療急性前骨髓性白血病(APL)。...

【Bryan】評論

The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. One of these compounds, mitomycin C, finds use as a chemotherapeutic agent by virtue of its antitumour antibiotic activity. It is given intravenously to treat upper gastro-intestinal, anal cancers, and breast cancers, as well as by bladder instillation for superficial bladder tumours. It causes delayed bone marrow toxicity and therefore it is usually administered at 6-weekly intervals. Prolonged use may result in permanent bone-marrow damage. It may also cause...

【Ru】評論

80.下列何者在細胞內經酵素還原成烷化劑後，與DNA反應形成交聯（cross-linked）結合物？ (A)Mitomycin (B)Methotrexate (C)Fludarabin (D)Vinorelbine