問題詳情

12 下列抗黴菌藥物中，何者以間歇療法（pulse therapy），即每一療程先服藥一星期後停藥三星期治療灰指甲（甲癬）為較佳的治療方式？
(A) itraconazole
(B) griseofulvin
(C) ketoconazole
(D) terbinafine

參考答案

答案：A
難度：適中0.462963
統計：A(75),B(28),C(2),D(34),E(0)

用户評論

【Bryan】評論

itraconazole 200mg bid 先服藥一星期後停藥三星期。

【1m】評論

itraconazoleOnychomycosis in Non-immunocompromised PatientsFingernails: 2 treatment pulses, each consisting of 200 mg q12hr for 1 weekToenails, with or without fingernail involvement: 200 mg/day PO for 12 weeksketoconazoleAvoid prescribing tablets to treat skin and nail fungal infections owing to risk of serious liver damage, adrenal gland problems, and harmful interactions with other medicines that outweigh its benefit in treating these conditions, which are not approved uses of the drug (these indications were removed from labeling by the FDA in 2013)terbinafineOnychomycosisIndicated for ony...

【XYZ】評論

Itraconazole為azole類抗黴菌藥，抑制C14 α-demethylase，阻斷lanosterol合成ergosterol，讓黴菌缺乏細胞膜主成分，達到抑菌效果。臨床上可用於治療灰指甲、麴菌感染。

【yu】評論

Itraconazole自皮膚與指甲之排泄較血液緩慢。皮膚感染時可於治療中止後2至4星期達到最佳的臨床及黴菌學反應；而指甲感染時則於治療中止後六至九個月達最佳反應。取自藥物仿單~