【ching】評論

Ezetimibe :(A)具有β-la☆☆☆☆ ★★...

【XXOO】評論

提供大家自己的一點想法～～（有錯再請大家糾正＞ ＜因為Ezetimibe 具glucuronide的活性代謝物所以需要OH 才能binding 所以OH是一定要留的喔！

【哈哈哈哈】評論

(A)具β-lactam環，此★★★★★☆☆☆1☆1...

【87 c】評論

抱歉我只有7版QQ原文：Using compound D as a lead, as well as in vivo data suggesting that metabolic transformations produced the active compound ultimately responsible for the cholesterol-lowering effect, structural modificationswere made that, eventually, led to the development of ezetimibe.The most important changes involved the introduction of hydroxyl groups to help localize the compound inthe intestine and the introduction ofp-fluoro groups to block undesirable metabolism. (P831)大概就是 Compound D 是雛形，然後改良成 ezetimibe，然後 OH 可以讓 ezetimibe 在腸道更專一、p-fluoro可以延長作用時...