【.】評論

(A) 正確，Patients with severe COPD may exhibit flow limitation even at rest, as reflected by the fact that they breathe tidally along or above their maximal flow-volume curve.(B) 正確，Resting hyperinflation (inspiratory capacity/total lung capacity) is associated with lower oxygen pulse, peak exercise inspiratory capacity/total lung capacity and exercise capacity in patients with severe COPD.(C) 錯誤，the high susceptibility to locomotor muscle fatigue in patients with COPD is in part attributable to insufficient O2 transport as a consequence of exaggerated arterial hypoxemia and/or excessive respiratory muscle work but also support a critical role for the well-known altered intrinsic muscle characteristics in these patients.(D) 正確，cardiovascular impairment might influence the results of timed walking tests and whether these tests might be sensitive enough for the assessment of pulmonary hypertension treatment in patients with COPD and pulmonary hypertension.REF: Pulm Med. 2012;2012:234145.Eur Respir J. 2008 Nov;32(5):1275-82.Am J Physiol Regul Integr Comp Physiol. 2010 Jul;299(1):R314-24.Eur Respir J. 2003 May;21(5):892-905.