【加賴叫過去】評論

digoxin的濃度增加跟P-gp比較有關係，所以一樣看下表：Inhibitors of P-gpInducers of P-gpAmiodaroneAbrocitinibAzithromycin (systemic)Cannabidiol and cannabidiol-containing coformulationsCapmatinibCarvedilolClarithromycinCobicistatCyclosporine (systemic)DaclatasvirDronedaroneElagolixEliglustatElexacaftor-tezacaftor-ivacaftorErythromycin (systemic)FlibanserinFostamatinibGlecaprevir-pibrentasvirIsavuconazoleItraconazoleIvacaftorKetoconazole (systemic)LapatinibLedipasvirLevoketoconazoleNeratinibOsimertinibPosaconazolePropafenoneQuinidineQuinineRanolazineRitonavirRolapitantSimeprevirTamoxifenTepotinibTezacaftor-ivacaftorTicagrelorTucatinibVelpatasvirVemurafenibVerapamilVoclosporinApalutamideCarbamazepineFosphenytoinGreen tea (Camellia sinensis)LorlatinibPhenytoinRifampin (rifampicin)St. John's wort

【terminator812】評論

我補充一下副作用和交互作用

【Tegralition】評論

applied 11e p293

【HUSpiTLE】評論

Digoxin與其他藥物的DDIDDI 藥物嚴重性/證據力作用機制作法AmiodaroneMajor/Excellent抑制p-gpIV or IM digoxin：劑量應降低15% to 30%PO digoxin：劑量應降低30% to 50% AmlodipineMajor/Fair加成digoxin對AV node傳導變慢的作用，增加心搏過緩、心臟傳導阻滯風險小心監測心律(HR)，適時降低劑量或停用DiltiazemMajor/Good抑制清除率；加成digoxin對AV node傳導變慢的作用PO digoxin：劑量應降低15% to 30%MetoprololModerate/GoodBeta blocker會加成digoxin對AV node傳導變慢的作用小心監測心律(HR)，適時降低劑量或停用VerapamilMajor/Excellent抑制腎臟清除率IV or IM digoxin：劑量應降低15% to 30%PO digoxin：劑量應降低30% to 50%此題不容易呀！但歸納出來方便記的方式是：beta-blocker對於digoxin影響不大；作用於周邊血管的CCB相對於作用於心臟的CCB影響較小。其他Amiodarone, Diltiazem, Verapamil都會影響digoxin的清除率。Ref: Micromedex—DDI

【國考游泳隊】評論

限制抑制P-gpVIPVerapmilItraconazolePropafenone訪問(ASK)AmiodaroneSpironolactoneKetoconazole賽(RACE)RitonavirAzithromycinClarithromycinErythromycin車CarvedilolQueenQuinidine