【Filgrastim zz】評論

考試當下 ③phenytoin ④rifampin 都是 enzyme inducer 刪掉直接選B：）dabigatran為P-glycoprotein受質，會受到p-gp inhibitor/inducer 的影響：ref: 普栓達膠囊150毫克 中文仿單

【加賴叫過去】評論

看到題目寫：血中濃度提高 --> 1. 抑制肝臟酵素代謝 (因為代謝降低藥物跑不出體外-->體內藥物濃度增加)2. P-gp抑制不過這題比較偏2. 因為Direct oral anticoagulants (DOACs)很多都會被p-gp排出，所以就背一下下表吧：Inhibitors of P-gpInducers of P-gpAmiodaroneAbrocitinibAzithromycin (systemic)Cannabidiol and cannabidiol-containing coformulationsCapmatinibCarvedilolClarithromycinCobicistatCyclosporine (systemic)DaclatasvirDronedaroneElagolixEliglustatElexacaftor-tezacaftor-ivacaftorErythromycin (systemic)FlibanserinFostamatinibGlecaprevir-pibrentasvirIsavuconazoleItraconazoleIvacaftorKetoconazole (systemic)LapatinibLedipasvirLevoketoconazoleNeratinibOsimertinibPosaconazolePropafenoneQuinidineQuinineRanolazineRitonavirRolapitantSimeprevirTamoxifenTepotinibTezacaftor-ivacaftorTicagrelorTucatinibVelpatasvirVemurafenibVerapamilVoclosporinApalutamideCarbamazepineFosphenytoinGreen tea (Camellia sinensis)LorlatinibPhenytoinRifampin (rifampicin)St. John's wortStrong inhibitorsModerate inhibitorsStrong inducersModerate inducersAtazanavirCeritinibClarithromycinCobicistatDarunavirIdelalisibIndinavirItraconazoleKetoconazoleLevoketoconazoleLonafarnibLopinavirMifepristoneNefazodoneNelfinavirPosaconazoleRitonavirSaquinavirTelithromycinTucatinibVoriconazoleAmiodaroneAprepitantBerotralstatCimetidineConivaptanCrizotinibCyclosporineDiltiazemDuvelisibDronedaroneErythromycinFedratinibFluconazoleFosamprenavirFosaprepitantGrapefruit juiceImatinibIsavuconazole LefamulinLetermovirNetupitantNilotinibRibociclibSchisandraVerapamilApalutamideCarbamazepineEnzalutamideFosphenytoinLumacaftorLumacaftor-ivacaftorMitotanePhenobarbitalPhenytoinPrimidoneRifampin (rifampicin)BexaroteneBosentanCenobamateDabrafenibDexamethasoneDipyroneEfavirenzEslicarbazepineEtravirineLorlatinibMitapivatModafinilNafcillinPexidartinibRifabutinRifapentineSotorasibSt. John's wort

【Tegralition】評論

applied 11e p4511e p17811e p17911e p317