問題詳情

50.有關排卵藥clomiphene citrate敘述,下列何者錯誤?
(A)主要可以治療促性腺激素低下型低性腺功能症(hypogonadotropic hypogonadism WHO group I)患者的無排卵現象
(B)選擇性雌激素接受器調節劑,可以影響雌激素負回饋反應,刺激濾泡發育
(C)治療的副作用可能包括子宮頸黏液分泌減少、子宮內膜生長受損以及多胞胎妊娠
(D)某些病患治療後仍然無法排卵時,可以結合胰島素增敏劑metformin,增加排卵的機會

參考答案

答案:A
難度:困難0.375
統計:A(9),B(4),C(4),D(2),E(0)

用户評論

霸氣阿宏】評論

由於hypogonadotropic hypogonadism 是本身無法分泌FSH與LH,因此抑制雌激素的副回饋仍然無法解決問題。須解決其根本因素,如: brain or pituitary tumors, pituitary apoplexy, head trauma, ingestion of certain drugs, and certain systemic diseases and syndromes.Mechanism of Action  (clomiphene)Clomiphene is a racemic mixture consisting of zuclomiphene (~38%) and enclomiphene (~62%), each with distinct pharmacologic properties. Clomiphene acts at the level of the hypothalamus, occupying cell surface and intracellular estrogen receptors (ERs) for longer durations than estrogen. This interferes with rece...