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依照Pharmacotherapy A ...
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paper解題 + 4選項解析 + ★★★★★★★ ...
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D: A potential clinical issue with aprepitant, fosaprepitant, and netupitant is that they are moderate inhibitors of the CYP3A4 metabolic pathway, and dose reduction may be needed for concurrently administered drugs that are primarily metabolized through CYP3A4. Rolapitant does not inhibit CYP3A4 but inhibits CYP2D6Ref: UpToDate
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ref: Recent Advances in Preventing Chemotherapy-Induced Nausea and VomitingAugust 16, 2016Syed Sameer Nasir, MD, Lee S. Schwartzberg, MD