問題詳情

31.有關下列4種neurokinin 1(NK1)receptor antagonists特性之敘述,下列何者正確?①aprepitant②fosaprepitant ③netupitant ④rolapitant
(A)與NK1受器的結合力排序:③>②>④>①
(B)排除半衰期:④>③>②=①
(C)預防化療引起的嘔吐之給藥頻率:①單次給藥,②單次給藥,③單次給藥,④每日一次
(D)抑制肝臟酵素CYP3A4的能力:①>②=③=④

參考答案

答案:B
難度:困難0.31
書單:沒有書單,新增

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瓜瓜樂】評論

依照Pharmacotherapy A ...

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paper解題 + 4選項解析 + ★★★★★★★ ...

HUSpiTLE】評論

D: A potential clinical issue with aprepitant, fosaprepitant, and netupitant is that they are moderate inhibitors of the CYP3A4 metabolic pathway, and dose reduction may be needed for concurrently administered drugs that are primarily metabolized through CYP3A4. Rolapitant does not inhibit CYP3A4 but inhibits CYP2D6Ref: UpToDate

粗暴言論duck不必】評論

ref: Recent Advances in Preventing Chemotherapy-Induced Nausea and VomitingAugust 16, 2016Syed Sameer Nasir, MD, Lee S. Schwartzberg, MD