【評論主題】73.Fluoxetine與下列何者為禁忌，不得併用？(A)moclobemide (B)risperidone (C)clozapine (D)trazodone
【評論內容】MAO-A (抗憂鬱)可逆：MoclobemideMAO-B (抗帕金森)可逆：Safinamide不可逆：~giline非選擇：Phenlzine, Tranylcypromine
【評論主題】80.有關diclofenac用於退化性關節炎之敘述，下列何者錯誤？(A)應監測腎功能 (B)長期使用增加胃腸道潰瘍的機率 (C)緩釋劑型減少胃腸道潰瘍的機率 (D)應監測肝功能
【評論內容】From 國考用書Koda 11th書裡只找到Diclofenec具肝毒的敘述如下：
Diclofenac is associated with elevations in alanine aminotransferase and aspartate aminotransferase levels; however, increases in aminotransferase levels alone are not predictive of liver injury. The FDA recognizes increases in both bilirubin and aminotransferase levels as surrogate markers for drug-induced liver disease.
【評論主題】61.濫用藥物依據藥理作用分為CNS depressants、CNS stimulants、hallucinogens。下列組合，何者不屬於同一類別？ (A)amphetamine & ecstasy
【評論內容】(D) Carisoprodol類似於BZD具中樞抑制以下From 國考用書Koda 11th：Benzodiazepines have become the prototypical sedative-hypnotic drugs of abuse. Other abused sedative-hypnotic drugs include carisoprodol and γ-hydroxybutyric acid (GHB).Carisoprodol：a nonscheduled skeletal muscle relaxant, has an active metabolite meprobamate, a sedative-hypnotic agent with known abuse potential.GHB：a putative neurotransmitter abused for its euphoric and sedative-hypnotic effects.
【評論主題】9.有關細菌性腦膿瘍（bacterial brain abscess）之敘述，下列何者錯誤？(A)常好發於中耳炎或鼻竇炎感染後 (B)常見的病原菌包括Bacteroides species，strep
【評論內容】
D一看就是錯的喔 因為Clinda☆☆☆☆☆...
【評論主題】38.下列何者最可能導致血鉀升高？(A)amphotericin B (B)furosemide (C)spironolactone (D)thiazide diuretics
【評論內容】
From國考用書Koda 11th
造成高血鉀：ACEI/ARB, NSAIDs, Succinylcholine, Cyclosporine, Tacrolimus, Lithium, Heparin, Pentamide治高血鉀新藥：Patiromer, Sodium Zirconium Cyclosalicate【評論主題】24.有關注射藥品之敘述，下列何者正確？(A)Clexane®（enoxaparin）是皮下注射用的prefilled syringe(B)paclitaxel水溶性低，製成注射劑時須以ethyl a
【評論內容】
From 國考用書Koda 11th
Cremophor EL: Paclitaxel, TeniposideBenzyl Alcohol: MTX (IV), Cytarabine, EtoposidePolysorbate 80: Docetaxel, EtoposideMethoxypolyethylene glycol: Liposomal Doxorubicin【評論主題】33.林先生，60公斤，動脈血氣體（ABG）分析為 ，若要將 增加到24 mEq/L， 應給與多少mEq之 NaHCO3？(A)60(B)120(C)180(D)240
【評論內容】
From 國考用書Koda 11t☆...
【評論主題】9.下列那個cephalosporin類藥品進入腦脊髓液的比例最低？(A)cefazolin(B)cefuroxime(C)cefotaxime(D)cefepime
【評論內容】不易穿過BBB：AMG, Macrolides, 一代cefa, Clindamycin, Daptomycin
【評論主題】18.有關angiotensin receptor-neprilysin inhibitor（ARNI）之敘述，下列何者正確？(A)可與captopril併用，以增加療效(B)活化renin-angi
【評論內容】<注意！>ACEI轉ARNI需間隔36小時
【評論主題】7.有關壞死性筋膜炎（necrotizing fasciitis）之敘述，下列何者最不適當？(A)若抗生素治療效果不佳時，再由外科醫師清創傷口(B)初始抗生素使用piperacillin/tazoba
【評論內容】
from Koda 11th：初期使用 抗G(-)+ G(+) 的抗生素
抗G(-)：Piperacillin/Tazo, Ampicillin/Sulbactam, or Carbapenem抗G(+)：選可抗MRSA (Vanco, Daptomycin, Linezolid)若確定病人有GAS (Group A Streptocooci)：則加上Clindamycin，因GAS最易導致Flesh-eating diseaseFlesh-eating disease治療：High dose Penicillin G + Clindamycin【評論主題】65.Colestipol最不可能引起下列何種不良反應？(A)便秘、腹部脹氣(B)降低脂溶性維生素之吸收(C)降低鹼性藥品的生體可用率(D)胃腸阻塞
【評論內容】From國考用書Koda 11th會降低帶負電藥物的吸收，如：warfarin, b-blocker, thyroxine, thiazide
【評論主題】78.有關抽藥的動作與目的，下列敘述何者正確？(A)將所有藥瓶上橡皮瓶塞以酒精棉片擦拭，是為了將瓶塞上的化療藥抹去 (B)使用螺旋頭（Luer lock）之針筒抽藥，以避免藥液由針頭滲漏 (C)抽出c
【評論內容】(B) From 國考指定用書：Luer lock syringes with wide-bore needles should be used for all procedures to allow free flow in the fluid pathway and to avoid the risk of syringes and needles becoming disconnected during fluid transfer
【評論主題】33.有關藥品引起之acneiform-erythematous rash，下列何者錯誤？(A)被報導最多的藥品是EGFR inhibitors、EGFR monoclonal antibodies
【評論內容】
補個Koda 11th的 Prevention:
Prevention is recommended in the majority of patients in the first 6 to 8 weeks of therapy and consists of hydrocortisone 1% cream with moisturizer, sunscreen, and either minocycline or doxycycline therapy
【評論主題】2.有關calamine lotion BP配方成分之作用，下列何者錯誤？(A)sodium citrate為矯味劑 (B)bentonite為增稠劑 (C)glycerol為增稠劑 (D)lique
【評論內容】
From國考用書 對於Calamine的整理：⚫ 功用:cooling lotion for sunburn or skin irritation and pruritus. Don’t apply to broken skin!! ⚫ 成分:
➢ Calamine is a coloured zinc carbonate 與氧化鋅同為 indiffusible solids ➢ Sodium citrate：控制凝絮➢ Bentonite、Glycerol：thickening agent、幫助藥物吸附於皮膚➢ Liquefied phenol: 防腐
⚫ 步驟:(1) Dry powders should be weighed and mixed in a mortar: So that the bentonite is well distributed. (2) 加入甘油(3) Sodium citrate 溶於水中, 再逐漸加入 mixture in the mortar, so that a paste is produced(4) Add liquefied phenol：Not to splash, as it is caustic
...【評論主題】60.下列何者最適合用於治療candiduria？(A)anidulafungin(B)fluconazole(C)posaconazole(D)voriconazole
【評論內容】From國考用書Loda 11th
Newer triazoles (voriconazole, posaconazole, and isavuconazole) or echinocandins are not recommended for the treatment of candiduria owing to their low concentrations in urine
【評論主題】53.有關colchicine之敘述，下列何者錯誤？(A)會抑制有絲分裂(B)過量會引起噁心、嘔吐、腹瀉(C)clarithromycin會降低其血中濃度(D)應避免靜脈注射給與
【評論內容】From 國考用書Koda 11thColchicine禁忌：併CYP inhibitor, 併P-gp inhibitor