【HUSpiTLE】評論

ref: micromedex--dic☆☆☆☆☆☆☆☆☆: ...

【Mos好好吃】評論

From 國考用書Koda 11th書裡只找到Diclofenec具肝毒的敘述如下：Diclofenac is associated with elevations in alanine aminotransferase and aspartate aminotransferase levels; however, increases in aminotransferase levels alone are not predictive of liver injury. The FDA recognizes increases in both bilirubin and aminotransferase levels as surrogate markers for drug-induced liver disease.

【Tegralition】評論

applied 11e p871applied 11e p891

【貓】評論

A, D需監測肝腎功能(臨床上比較小心腎功能惡化)，腎太爛可能促成AKIB. 長期使用會增加胃潰瘍因為除了ΘCOX-2，也會ΘCOX-1，導致具胃上皮細胞cytoprotection的prostaglandin E銳減→促成COX-2 selective inhibitor(-coxib)研發→PGE1 analog: Misoprostol, 預防NSAID引發的PUD(胃潰瘍)C. 緩釋劑型的目的:減少服藥頻次，增加服藥配合性eg. Deflam*(25) IR: #1 tid-qidVotan*(100) SR(持續釋放): #1 qd