3. Which of following description about opioid receptors is "Incorrect" ?
(A) Opioid receptors belong to the superfamily of G protein–coupled receptors (GPCR)
(B) Opioid receptors are coupled to Gs protein to trigger downstream signaling.
(C) Overall opioid receptor activation leads to inhibit neuronal activity
(D) In spinal cord level, opioid receptors are located mostly in the superficial dorsal horn
(E) Endogenous opiates maybe released by immune cells and work on both central and peripheralopioid receptors.