【terminator812】評論

(D) 發燒使用 cisatracurium 後，發燒可能能加速該藥的排除。解釋： cisatracurium 是一種非去極化性肌肉松弛劑，通常用於手術過程中，以幫助在麻醉下保持肌肉松弛。它的作用是在神經-肌肉接頭中阻斷神經傳遞，使肌肉無法收縮，從而實現松弛的效果。當患者使用 cisatracurium 後發燒，發燒可能會引起患者的新陳代謝增加。發燒時，體溫升高會增加心跳、呼吸頻率以及代謝速率。這些生理變化可能會促進藥物的代謝和排泄。其他選項的情形則相反：(A) 酸中毒：酸中毒可能會降低藥物的代謝和排泄，因為酸中毒會影響體內藥物代謝酵素的功能。(B) 腎功能不全：腎功能不全可能會導致藥物在體內排泄速度減緩，藥物停留在體內的時間增加。(C) 低血磷：低血磷可能會對體內的代謝過程產生影響，但與加速 cisatracurium 排除的關聯性較弱。

【貓貓肉】評論

71.下列何者會降低cisatracurium之排除而增加藥品不良反應？(A) metabolic acidosis(B) hyperthermia(C) hyperphosphatemia(D) metabolic alkalosis專技 - 調劑學與臨床藥學-111年 - 111-2 專技高考_藥師（二）：調劑學與臨床藥學#109898

【passpass】評論

71.下列何者會降低cisatracurium之排除而增加藥品不良反應？

【帕拉迪島巨人】評論

酸中毒會下降神經肌肉阻斷劑排除下列何者會降低cisatracurium之排除而增加藥品不良反應？

【IG:Pharmabook】評論

11th applied p.47cisatracurium的藥物動力學  Cisatracurium 會經過Hofmann degradation，理想的降解時機為37°C、PH=7.4因此更改溫度與PH值會改變降解速度鹼性能加速排除→(A)酸中毒會延緩排除溫度上升會加速排除→EX：(D)發燒Cisatracurium不受肝腎功能而影響其排除→(B)腎功能低下不影響(C)低血磷會抑制排除 cisatracurium, is a benzylisoquinolinium compound. It is primarily eliminated by Hofmann degradation; optimal breakdown occurs at physiologic temperature (37°C or 98.6°F) and pH (7.40).However, because cisatracurium is degraded by the Hofmann process, alterations in pH and temperaturewill affect the elimination of the drug.For example, the neuromuscular blockade effect is prolonged with acidosis(A) while elimination is enhanced with an increase in pH. Additionally, hypothermia decreases the elimination of cisatracurium whereashyperthermia (B) accelerates itBecause M.M. has evidence of both significant renal and hepatic impairment, cisatracurium or atracurium would be appropriate choices for a neuromuscular blocking agent because their properties are not altered significantly by renal and hepatic failureJ.A. may need a longer period than an hour and one-half to recover from his paralysis because of the following factors: decreased elimination of cisatracurium as a result of acidosis, hypophosphatemia, and medications (amikacin andhydrocortisone). J.A. should also have his phosphate slowly repleted.