【陳厚德】評論

(A) diltiazem：P-gp inh.

【HO】評論

cyclosporine and ticlopidine coadministration may result in a reduction of cyclosporine levels . Ticlopidine may cause an induction of the cytochrome P450 3A4 system, resulting in an increase in the rate of cyclosporine metabolism.在cyclosporine 的仿單中也確實有(A)diltiazem是CYP3A4抑制劑(B)indinavir為CYP3A4受體，會競爭導致Cyclosporine代謝減少(C)fluvoxamine同樣是CYP3A4抑制劑

【passpass】評論

Micromedex68.下列何者最不會降低cyclosporine的療效？(A)葡萄柚汁(B)貫葉連翹（St. John's wort）(C)制酸劑(D)cholestyramine編輯私有筆記及自訂標籤

【帕拉迪島巨人】評論

A 3A4 inhibitorB 3A4 inhibitorC 1A2代謝D 2C19

【dd5252011】評論

p-gp substrate與CYP 3A4相近，除了digoxin及dabigatran僅為p-gp substrate，另選項ABC都是歷年常考的inhibitor(藥物併用增加藥效)，故選D