【Bryan】評論

Daunorubicin or daunomycin is chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. It is most commonly used to treat specific types of leukemia. It was initially isolated from Streptomyces peucetius.

【chaochao.hsie】評論

Doxorubicin  Epirubicin Daunorubicin Idarubicin Valrubicin Mitoxantrone

【一臉厭世讀國考】評論

字尾有-rubicin的都是Anthracycline glycoside構造

【所得皆所愿】評論

Anthracycline：經還原酶形成Hydroquinone+超氧離子> 結構：胺醣類、O-glycoside、C7-L-daunosamine、Fe2+螯合C11、12> 嵌入DNA，抑制Topo II> Hydroquinone產自由基（Doxorubicinol→心毒性）Doxorubicin（小紅莓）廣泛：治乳癌、肺癌、急性白血病（淋巴性ALL、骨髓性AML）Daunorubicin（C14少一個OH）治急性白血病（ALL、AML）Idarubicin（C1少OCH3）治急性骨髓性白血病AMLEpirubicin治乳癌> 副作用：不可逆的劑量依賴心毒性、嚴重掉髮、紅色尿液（Quinone代謝）***心臟毒性：Daunorubicin、Doxorubicin > Idarubicin、Epirubici...