問題詳情

25. Which of the following compounds is a suicide inhibitor of aconitase?
(A) citrate
(B) fluoroacetate
(C) isocitrate
(D) acetyl-CoA
(E) FADHz.

參考答案

答案:[無官方正解]
難度:計算中-1
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各選項詳解】評論

(B)為正解Aconitase is an enzyme that catalyzes the conversion of citrate to isocitrate in the tricarboxylic acid (TCA) cycle. It is a key enzyme in the metabolism of carbohydrates, fats, and proteins, and is important for the production of energy in cells.(B)Fluoroacetate is a compound that is toxic to animals and plants. It is a suicide inhibitor of aconitase because it binds covalently to the active site of the enzyme and irreversibly inactivates it. This prevents the enzyme from functioning and disrupts the TCA cycle, leading to the accumulation of citrate and a decrease in energy production.Citrate, isocitrate, acetyl-CoA, and FADH2 are all intermediates or products of the TCA cycle. They are not suicide inhibitors of aconitase.