【用戶】吳富豪
【年級】高三下
【評論內容】Goals of therapyThe goal of antiviral therapy in patients with chronic hepatitis C virus (HCV) is to eradicate HCV RNA, which is predicted by attainment of a sustained virologic response (SVR), defined as an undetectable RNA level 12 weeks following the completion of therapyAdditional monitoring for HBV coinfection Patients with evidence of prior or current HBV infection (ie, those with positive HBV core antibody [HBcAb]) who are not on HBV antiviral therapy warrant specific monitoring because of the risk of HBV reactivation during HCV treatmentgenotype太多基因型了先測量是哪一種才好對症下藥 太多了只列一些現已有全基因型的的DAA(oral)，interferon(SC)已不是首選
【用戶】IG:Pharmabook
【年級】高一上
【評論內容】各選項解析 from 10th pharmacotherapy : a pathophysiologic approach (C)選項以往注射干擾素會引起很大的副作用因此現行guideline建議口服藥品是現今的標準治療 The treatment of chronic HCV was revolutionized with the approval of DAAs. Previously the treatment backbone included the injection of peg-IFN and was associated with a substantialside-effect profile. The current standard of care for all chronic HCV infections, regardless of GT, is an all-oral regimen----------------------------------------------------------------------------------------------------------------------(A)C肝的治療目標是完全清除C肝病毒，達到sustained virologic response (SVR) (SVR 定義：完成HCV療程後12周偵測不到HCV病毒)The primary goal of therapy is to eradicate HCV infection. Virologic cure, or sustained virologicresponse (SVR), is defined as a nondetectable HCV RNA at least 12 weeks after completing HCVtherapy.----------------------------------------------------------------------------------------------------------------------(B)所有的HCV病人應同時接踵A、B肝疫苗(在HCV治療期間HBV有復發風險)→應同時評估病人是否有hepatitis BAll chronic HCV patients should be vaccinated against hepatitis A and B ---------------------------------------------------------------------------------------------------------------------(D)治療前應進行病毒基因型及病毒定量檢驗病毒定量檢驗：可確認HCV感染、決定是否適用短期治療、監測藥物治療後的反應病毒基因型：不同基因型會有不同長度的治療時間Before therapy is initiated, quantitative HCV testing and genotyping are performed.Quantitative amplification assays for HCV RNA are performed to confirm chronic HCV infection, can serve toidentify candidates for a shortened duration of therapy, and are used to monitor virologic responseonce therapy is initiated. Genotyping is also necessary because duration of therapy varies depending on the infecting GT.
【用戶】吳富豪
【年級】高三下
【評論內容】Goals of therapyThe goal of antiviral therapy in patients with chronic hepatitis C virus (HCV) is to eradicate HCV RNA, which is predicted by attainment of a sustained virologic response (SVR), defined as an undetectable RNA level 12 weeks following the completion of therapyAdditional monitoring for HBV coinfection Patients with evidence of prior or current HBV infection (ie, those with positive HBV core antibody [HBcAb]) who are not on HBV antiviral therapy warrant specific monitoring because of the risk of HBV reactivation during HCV treatmentgenotype太多基因型了先測量是哪一種才好對症下藥 太多了只列一些現已有全基因型的的DAA(oral)，interferon(SC)已不是首選
【用戶】IG:Pharmabook
【年級】高一上
【評論內容】各選項解析 from 10th pharmacotherapy : a pathophysiologic approach (C)選項以往注射干擾素會引起很大的副作用因此現行guideline建議口服藥品是現今的標準治療 The treatment of chronic HCV was revolutionized with the approval of DAAs. Previously the treatment backbone included the injection of peg-IFN and was associated with a substantialside-effect profile. The current standard of care for all chronic HCV infections, regardless of GT, is an all-oral regimen----------------------------------------------------------------------------------------------------------------------(A)C肝的治療目標是完全清除C肝病毒，達到sustained virologic response (SVR) (SVR 定義：完成HCV療程後12周偵測不到HCV病毒)The primary goal of therapy is to eradicate HCV infection. Virologic cure, or sustained virologicresponse (SVR), is defined as a nondetectable HCV RNA at least 12 weeks after completing HCVtherapy.----------------------------------------------------------------------------------------------------------------------(B)所有的HCV病人應同時接踵A、B肝疫苗(在HCV治療期間HBV有復發風險)→應同時評估病人是否有hepatitis BAll chronic HCV patients should be vaccinated against hepatitis A and B ---------------------------------------------------------------------------------------------------------------------(D)治療前應進行病毒基因型及病毒定量檢驗病毒定量檢驗：可確認HCV感染、決定是否適用短期治療、監測藥物治療後的反應病毒基因型：不同基因型會有不同長度的治療時間Before therapy is initiated, quantitative HCV testing and genotyping are performed.Quantitative amplification assays for HCV RNA are performed to confirm chronic HCV infection, can serve toidentify candidates for a shortened duration of therapy, and are used to monitor virologic responseonce therapy is initiated. Genotyping is also necessary because duration of therapy varies depending on the infecting GT.