【最後一哩路加油】評論

在急性冠心症的患者中有文獻指出 nicardipine 會有血液動力學相關的影響The haemodynamic dose-response effects of the slow-calcium channel blocker nicardipine were evaluated in fifteen male patients with uncomplicated acute myocardial infarction.Following a 1 hr control period, during which the stability of base-line control haemodynamic variables was confirmed, four i.v. boluses of 1.25, 1.25, 2.5 and 5.0 mg of the drug (cumulative dosage 1.25, 2.5, 5.0 and 10.0 mg) were administered at 15 min intervals. The plasma concentrations achieved are within the previously described therapeutic range (greater than 20 micrograms/l). 血中濃度給予後有超出預期ㄉㄜ增加Nicardipine resulted in linear reductions in systemic arterial pressure and vascular resistance, and dose-related increases in heart rate, cardiac and stroke output without change in the left heart filling pressure. Intravenous nicardipine did not induce any depression of left ventricular pumping performance in our patients in the early stages of uncomplicated myocardial infarction.  nicardipine會有劑量相關的心跳增加來源 https://pubmed.ncbi.nlm.nih.gov/6527977/

【Zoan】評論

Nicardipine是一種二氫吡啶型鈣通道阻滯劑，可用於治療高血壓和其他心血管疾病。對於stable ischemic heart disease（穩定型心臟缺血症）或acute coronary syndrome（急性冠狀動脈綜合症）的患者，nicardipine不是首選的治療藥物。這是因為nicardipine是一種非選擇性的鈣通道阻滯劑，它對心臟和血管的鈣通道都有作用。對於心臟血管疾病患者來說，選擇性的鈣通道阻滯劑，特別是二氫吡啶類（dihydropyridine）鈣通道阻滯劑，如amlodipine、felodipine和lercandipine，更受到推薦。這些二氫吡啶類鈣通道阻滯劑對冠狀動脈的選擇性更高，不太會對心臟的收縮功能產生不良影響，因此在穩定型心臟缺血症或急性冠狀動脈綜合症患者中更安全且更常用。

【吳富豪】評論

這題好像考過不少次nicardipine就是比較特別，CCB裡不會選他Angina/MI:Increased angina (frequency, duration, or severity) and/or MI has occurred. Reflex tachycardia may occur resulting in angina and/or MI in patients with obstructive coronary disease, especially in the absence of concurrent beta blockade.資料來源:Up to date

【OOO】評論

口訣: nicardipine = ni(否定)-cardi(心血管)-pinenicardipine不適用於急性心血管疾病~~~