【用戶】吳富豪
【年級】高三下
【評論內容】Amiodarone結構含碘，可能導致甲狀腺機能異常Amiodarone半衰期長，起始作用需數週Single dose: 58 days (range: 15 to 142 days)Oral chronic therapy: Mean range: 40 to 55 days (range: 26 to 107 days)DronedaroneHalf-life elimination: 13 to 19 hours 差太多了~~Amiodarone半衰期長，起始作用需數週dronedarone與digoxin是有DDI的喔!!May enhance the AV-blocking effect of Dronedarone. Digoxin may also enhance the other electrophysiologic effects of Dronedarone. Dronedarone may increase the serum concentration of Digoxin.濃度上升→Management: Avoid concurrent use of digoxin when possible避免並用
【用戶】IG:Pharmabook
【年級】高一上
【評論內容】dronedarone vs amiodarone 考點統整比較表 DronedaroneAmiodarone結構結構不含碘 (A)含碘商品名MultaqCordarone半衰期短(13-19hr)(C)長 (15-10天)Vd大小甲狀腺異常副作用較小較大維持竇性心律（sinus rhythm）較弱較強臨床應用不可用於非代償性心衰竭（decompensated heart failure）病人維持竇性心律（sinus rhythm）代謝CYP3A4 substrate, CYP 2D6, 3A4 inhibitor,P-glycoprotein inhibitorCYP1A2, 2D6, 2C9, 3A4 inhibitor, P-glycoprotein inhibitor (B)digoxin DDI增加2.5倍濃度(D)增加濃度Ref：10th pharmacotherapy : a pathopysiological approach、pharmabook 藥治統整表格30.Dronedarone 之 plasma half-life 為何？
【用戶】dd5252011
【年級】大一上
【評論內容】半衰期碘VdCYP/p-gp 抑制劑結構性心臟病&心衰SEamiodarone15-100天V大(脂溶性高)V適用與dronedarone一樣:GI、心搏徐緩不一樣:肺纖維化、甲狀腺異常、周邊神經病變、肝功能異常、光敏感、角膜沉積、blue gray skin、低血壓(IV use)dronedarone1天X小X不適用GI、心搏徐緩(惡化心衰)
【用戶】吳富豪
【年級】高三下
【評論內容】Amiodarone結構含碘，可能導致甲狀腺機能異常Amiodarone半衰期長，起始作用需數週Single dose: 58 days (range: 15 to 142 days)Oral chronic therapy: Mean range: 40 to 55 days (range: 26 to 107 days)DronedaroneHalf-life elimination: 13 to 19 hours 差太多了~~Amiodarone半衰期長，起始作用需數週dronedarone與digoxin是有DDI的喔!!May enhance the AV-blocking effect of Dronedarone. Digoxin may also enhance the other electrophysiologic effects of Dronedarone. Dronedarone may increase the serum concentration of Digoxin.濃度上升→Management: Avoid concurrent use of digoxin when possible避免並用
【用戶】IG:Pharmabook
【年級】高一上
【評論內容】dronedarone vs amiodarone 考點統整比較表 DronedaroneAmiodarone結構結構不含碘 (A)含碘商品名MultaqCordarone半衰期短(13-19hr)(C)長 (15-10天)Vd大小甲狀腺異常副作用較小較大維持竇性心律（sinus rhythm）較弱較強臨床應用不可用於非代償性心衰竭（decompensated heart failure）病人維持竇性心律（sinus rhythm）代謝CYP3A4 substrate, CYP 2D6, 3A4 inhibitor,P-glycoprotein inhibitorCYP1A2, 2D6, 2C9, 3A4 inhibitor, P-glycoprotein inhibitor (B)digoxin DDI增加2.5倍濃度(D)增加濃度Ref：10th pharmacotherapy : a pathopysiological approach、pharmabook 藥治統整表格30.Dronedarone 之 plasma half-life 為何？
【用戶】dd5252011
【年級】大一上
【評論內容】半衰期碘VdCYP/p-gp 抑制劑結構性心臟病&心衰SEamiodarone15-100天V大(脂溶性高)V適用與dronedarone一樣:GI、心搏徐緩不一樣:肺纖維化、甲狀腺異常、周邊神經病變、肝功能異常、光敏感、角膜沉積、blue gray skin、低血壓(IV use)dronedarone1天X小X不適用GI、心搏徐緩(惡化心衰)